Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.39 |
| ▸ | JAK1 | P23458 | 7/20 | 0.39 |
| ▸ | JAK3 | P52333 | 7/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3715478 | 0.81 | AURKA (0.44) | JAK3MAPT | |
| SCHEMBL3720780 | 0.80 | JAK3 (0.43) | JAK2JAK1JAK3IRAK4TYK2 | |
| SCHEMBL914111 | 0.79 | ABL1 (0.41) | JAK2JAK1JAK3IRAK4TYK2 | |
| SCHEMBL3715747 | 0.79 | JAK3 (0.43) | JAK2JAK1JAK3IRAK4TYK2 | |
| SCHEMBL914824 | 0.78 | ABL1 (0.39) | JAK2JAK1JAK3IRAK4TYK2 | |
| SCHEMBL12904687 | 0.77 | IRAK4 (0.48) | JAK2JAK1JAK3IRAK4TYK2 | |
| SCHEMBL3712327 | 0.77 | JAK3 (0.46) | JAK2JAK1JAK3IRAK4TYK2 | |
| SCHEMBL913949 | 0.76 | IRAK4 (0.65) | JAK2JAK1JAK3IRAK4TYK2 | |
| SCHEMBL913948 | 0.76 | IRAK4 (0.65) | JAK2JAK1JAK3IRAK4TYK2 | |
| SCHEMBL2713982 | 0.76 | FAAH (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |