Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.42 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.42 |
| ▸ | ECE1 | P42892 | 3/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30547455 | 0.90 | ELANE (0.44) | ELANEPRTN3ECE1MMENPC1 | |
| SCHEMBL7208522 | 0.87 | NPC1 (0.44) | ELANEPRTN3ECE1MMENPC1 | |
| SCHEMBL7212923 | 0.87 | NPC1 (0.44) | ELANEPRTN3ECE1MMENPC1 | |
| SCHEMBL4282571 | 0.87 | CA1 (0.46) | ELANEECE1MMENPC1RAB9A | |
| SCHEMBL4282703 | 0.87 | CA1 (0.46) | ELANEECE1MMENPC1RAB9A | |
| SCHEMBL27536452 | 0.87 | CA1 (0.46) | ELANEECE1MMENPC1RAB9A | |
| SCHEMBL27994897 | 0.84 | NPC1 (0.45) | ELANEPRTN3ECE1MMENPC1 | |
| SCHEMBL10004179 | 0.83 | NPC1 (0.49) | ELANEPRTN3NPC1RAB9AALDH1A1 | |
| SCHEMBL28449915 | 0.82 | CTSK (0.46) | CTSLCTSBCTSSCTSK | |
| SCHEMBL28464084 | 0.82 | ACP3 (0.44) | ECE1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2658857-B1 | SUBSTITUTED PURINE NUCLEOSIDES, PHOSPHOROAMIDATE AND PHOSPHORODIAMIDATE DERIVATIVES FOR TREATMENT OF VIRAL INFECTIONS | INHIBITEX INC (US) | 2016-11-02 | — | — | EP | disclosed |
| WO-2010081082-A2 | PHOSPHORAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INFECTIONS | UNIVERSITY COLLEGE OF CARDIFF CONSULTANTS LIMITED (GB) | 2010-07-15 | — | — | WO | disclosed |