Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720812 | 0.85 | LMNA (0.59) | LMNASMN1; SMN2HSD17B10PMP22MEN1 | |
| SCHEMBL3727012 | 0.85 | PARP1 (0.51) | LMNASMN1; SMN2HSD17B10USP2CYP3A4 | |
| SCHEMBL3717048 | 0.81 | KDM4E (0.52) | LMNAHSD17B10PARP1PARP2ALDH1A1 | |
| SCHEMBL3797911 | 0.80 | KDM4E (0.56) | LMNAHSD17B10MEN1KMT2APARP1 | |
| SCHEMBL3717692 | 0.80 | KDM4E (0.55) | LMNAHSD17B10PARP1PARP2ALDH1A1 | |
| SCHEMBL3721797 | 0.80 | KDM4E (0.52) | LMNASMN1; SMN2HSD17B10PARP1PARP2 | |
| SCHEMBL3721070 | 0.78 | KDM4E (0.53) | LMNAHSD17B10PARP1PARP2ALDH1A1 | |
| SCHEMBL3717027 | 0.78 | KDM4E (0.52) | LMNAHSD17B10ALDH1A1KDM4EHTT | |
| SCHEMBL3717909 | 0.78 | KDM4E (0.49) | LMNAHSD17B10ALDH1A1KDM4EHTT | |
| SCHEMBL3724662 | 0.77 | KDM4E (0.73) | LMNASMN1; SMN2HSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |