Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 14/20 | 0.54 |
| ▸ | KDR | P35968 | 8/20 | 0.54 |
| ▸ | STK3 | Q13188 | 7/20 | 0.54 |
| ▸ | MAP4K5 | Q9Y4K4 | 7/20 | 0.54 |
| ▸ | CSF1R | P07333 | 7/20 | 0.54 |
| ▸ | RET | P07949 | 6/20 | 0.54 |
| ▸ | LCK | P06239 | 6/20 | 0.54 |
| ▸ | TAOK1 | Q7L7X3 | 6/20 | 0.54 |
| ▸ | FLT1 | P17948 | 5/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.54 |
| ▸ | FYN | P06241 | 4/20 | 0.54 |
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | ROS1 | P08922 | 2/20 | 0.54 |
| ▸ | BTK | Q06187 | 2/20 | 0.54 |
| ▸ | GSK3B | P49841 | 2/20 | 0.54 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.54 |
| ▸ | PAK4 | O96013 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3720373 | 0.92 | EGFR (0.58) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3723424 | 0.90 | IGF1R (0.52) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3755296 | 0.90 | IGF1R (0.48) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3719815 | 0.89 | IGF1R (0.68) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3722526 | 0.84 | KDR (0.54) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3765186 | 0.83 | KDR (0.52) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3769707 | 0.81 | IGF1R (0.62) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3720235 | 0.80 | IGF1R (0.65) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3752529 | 0.80 | IGF1R (0.60) | IGF1RKDRSTK3MAP4K5CSF1R | |
| SCHEMBL3722541 | 0.78 | IGF1R (0.48) | IGF1RKDRSTK3MAP4K5CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435435-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-01-29 | — | — | EP | claimed |
| US-8536180-B2 | Pyrimidine inhibitors of kinase activity | ABBVIE INC. (US) | 2013-09-17 | — | — | US | claimed |
| WO-2010138575-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | claimed |
| US-20100305118-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | claimed |
| EP-2435435-B1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBVIE INC (US) | 2014-01-29 | — | — | EP | disclosed |
| US-8536180-B2 | Pyrimidine inhibitors of kinase activity | ABBVIE INC. (US) | 2013-09-17 | — | — | US | disclosed |
| WO-2010138575-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | WO | disclosed |
| US-20100305118-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | ABBOTT LABORATORIES (US) | 2010-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100305118-A1 | PYRIMIDINE INHIBITORS OF KINASE ACTIVITY | IGF1R, TK1, CDK2 | IGF1R 1/4885KDR 351/4885STK3 599/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.