Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | KDM6B | O15054 | 2/20 | 0.52 |
| ▸ | KDM5C | P41229 | 2/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.52 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.52 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3710216 | 0.89 | KDM4E (0.56) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL3714187 | 0.88 | ALDH1A1 (0.51) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL3709493 | 0.86 | KDM4E (0.59) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL3709550 | 0.83 | KDM4E (0.52) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL3714564 | 0.80 | KDM4E (0.49) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL27997808 | 0.80 | KDM4E (0.69) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL3716444 | 0.79 | KDM4E (0.63) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL1579012 | 0.79 | KDM4E (0.67) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL3719681 | 0.78 | KDM4E (0.47) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL3788730 | 0.78 | KDM4E (0.46) | KDM4EKDM6BKDM5CKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |