Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10646425 | 0.79 | KDM4E (0.36) | KDM4EALDH1A1MAPTHSD17B10EPAS1 | |
| SCHEMBL9487343 | 0.71 | KDM4E (0.37) | KDM4EALDH1A1MAPTHSD17B10EPAS1 | |
| SCHEMBL30987223 | 0.70 | MAPT (0.60) | KDM4EALDH1A1MAPTHSD17B10EPAS1 | |
| SCHEMBL28563540 | 0.70 | MAPT (0.60) | KDM4EALDH1A1MAPTHSD17B10EPAS1 | |
| SCHEMBL2941445 | 0.67 | MAPT (0.41) | KDM4EALDH1A1MAPTHSD17B10EPAS1 | |
| SCHEMBL20327723 | 0.67 | MAPK14 (0.41) | KDM4EALDH1A1MAPTHSD17B10EPAS1 | |
| SCHEMBL2679046 | 0.66 | KDM4E (0.40) | KDM4EALDH1A1MAPTHSD17B10EPAS1 | |
| SCHEMBL3462050 | 0.65 | TOP2A (0.50) | KDM4EALDH1A1MAPTHSD17B10 | |
| SCHEMBL9704343 | 0.64 | CYP2A6 (0.35) | — | |
| SCHEMBL6964514 | 0.63 | KDM4E (0.52) | KDM4EALDH1A1MAPTHSD17B10EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3273964-A1 | METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES | T3D Therapeutics Inc. (US) | 2018-01-31 | — | — | EP | claimed |
| WO-2016154258-A1 | METHODS OF TREATING LIVER DISEASE USING INDANE ACETIC ACID DERIVATIVES | T3D THERAPEUTICS, INC. (US) | 2016-09-29 | — | — | WO | claimed |
| WO-2012074980-A2 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISORDERS AND LIVER DISORDERS USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2012-06-07 | — | — | WO | claimed |
| WO-2010141696-A1 | METHODS OF TREATING OR PREVENTING PSORIASIS, AND/OR ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2010-12-09 | — | — | WO | claimed |
| WO-2012074980-A2 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISORDERS AND LIVER DISORDERS USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2012-06-07 | — | — | WO | disclosed |
| WO-2010141696-A1 | METHODS OF TREATING OR PREVENTING PSORIASIS, AND/OR ALZHEIMER'S DISEASE USING INDANE ACETIC ACID DERIVATIVES | DARA BIOSCIENCES, INC. (US) | 2010-12-09 | — | — | WO | disclosed |