Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.67 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.51 |
| ▸ | HTR3A | P46098 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1542155 | 1.00 | CHRNA7 (0.67) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL1542249 | 1.00 | CHRNA7 (0.67) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL1542520 | 0.89 | CHRNA7 (0.73) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL1542518 | 0.89 | CHRNA7 (0.73) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL412336 | 0.87 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL1146038 | 0.87 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL1908548 | 0.87 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL8266486 | 0.87 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL1145977 | 0.87 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL1145298 | 0.87 | CHRNA7 (0.52) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080234311-A1 | IMMUNOASSAY FOR DETECTION AND QUANTIFICATION OF AMYLOID-beta PEPTIDES | ABBVIE INC. | 2008-09-25 | — | — | US | claimed |
| US-20140234270-A1 | TREATMENT WTH ALPHAT SELECTIVE LIGANDS | TARGACEPT, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| EP-2484363-A1 | (2S,3R)-N-(2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-5-methylthiophene-2-carboxamide | Targacept, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| EP-2409703-A1 | Treatment with alpha7-selective ligands | Targacept, Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| US-20110262407-A1 | TREATMENT WITH ALPHA7 SELECTIVE LIGANDS | TARGACEPT, INC. (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110124678-A1 | TREATMENT WITH ALPHA 7-SELECTIVE LIGANDS | TARGACEPT, INC. (US) | 2011-05-26 | — | — | US | disclosed |
| US-20080234311-A1 | IMMUNOASSAY FOR DETECTION AND QUANTIFICATION OF AMYLOID-beta PEPTIDES | ABBVIE INC. | 2008-09-25 | — | — | US | disclosed |
| US-20050137204-A1 | Fused bicycloheterocycle substituted quinuclidine derivatives | ABBOTT LABORATORIES | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140234270-A1 | TREATMENT WTH ALPHAT SELECTIVE LIGANDS | CHRNA7, CHRNA2, CHRNA4 | CHRNA7 1/4885CHRNB2 6/4885CHRNA4 3/4885 |
| US-20110124678-A1 | TREATMENT WITH ALPHA 7-SELECTIVE LIGANDS | CHRNA7, CHRNA1, CHRNG | CHRNA7 1/4885CHRNB2 17/4885CHRNA4 9/4885 |
| US-20050137204-A1 | Fused bicycloheterocycle substituted quinuclidine derivatives | CHRNA1, CHRNA7, CHRNA2 | CHRNA7 2/4885CHRNB2 12/4885CHRNA4 10/4885 |
| US-20080234311-A1 | IMMUNOASSAY FOR DETECTION AND QUANTIFICATION OF AMYLOID-beta PEPTIDES | APP, IAPP, BACE1 | CHRNA7 235/4885CHRNB2 30/4885CHRNA4 80/4885 |
| US-20110262407-A1 | TREATMENT WITH ALPHA7 SELECTIVE LIGANDS | CHRNA7, CHRNA4, CHRNA2 | CHRNA7 1/4885CHRNB2 6/4885CHRNA4 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.