Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL910629 | 0.99 | KCNH2 (0.39) | KCNH2TOP2ASLC2A1MCHR1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL910544 | 0.99 | KCNH2 (0.39) | KCNH2TOP2ASLC2A1MCHR1SMN1; SMN2 | |
| SCHEMBL910317 | 0.88 | KCNH2 (0.39) | KCNH2TOP2A | |
| SCHEMBL3727967 | 0.88 | KCNH2 (0.39) | KCNH2TOP2A | |
| Hydrochloric Acid SCHEMBL3731742 | 0.87 | KCNH2 (0.39) | KCNH2TOP2A | |
| Hydrochloric Acid SCHEMBL910464 | 0.87 | KCNH2 (0.39) | KCNH2TOP2A | |
| SCHEMBL909985 | 0.86 | KCNH2 (0.49) | KCNH2TOP2ASLC2A1 | |
| SCHEMBL910083 | 0.86 | KCNH2 (0.35) | KCNH2TOP2ASLC2A1 | |
| Hydrochloric Acid SCHEMBL910352 | 0.86 | KCNH2 (0.49) | KCNH2TOP2ASLC2A1 | |
| Hydrochloric Acid SCHEMBL910105 | 0.86 | KCNH2 (0.35) | KCNH2TOP2ASLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238138-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | Glaxo Group Limited (GB) | 2010-10-13 | — | — | EP | claimed |
| WO-2009087153-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2009-07-16 | — | — | WO | claimed |