Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727967 | 1.00 | KCNH2 (0.39) | KCNH2TOP2ABCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL3731742 | 0.99 | KCNH2 (0.39) | KCNH2TOP2ABCHEACHEBACE1 | |
| Hydrochloric Acid SCHEMBL910464 | 0.99 | KCNH2 (0.39) | KCNH2TOP2ABCHEACHEBACE1 | |
| SCHEMBL3721771 | 0.88 | KCNH2 (0.39) | KCNH2TOP2A | |
| Hydrochloric Acid SCHEMBL910544 | 0.87 | KCNH2 (0.39) | KCNH2TOP2A | |
| Hydrochloric Acid SCHEMBL910629 | 0.87 | KCNH2 (0.39) | KCNH2TOP2A | |
| SCHEMBL909985 | 0.86 | KCNH2 (0.49) | KCNH2TOP2A | |
| Hydrochloric Acid SCHEMBL910352 | 0.85 | KCNH2 (0.49) | KCNH2TOP2A | |
| SCHEMBL910083 | 0.81 | KCNH2 (0.35) | KCNH2TOP2A | |
| Hydrochloric Acid SCHEMBL910105 | 0.81 | KCNH2 (0.35) | KCNH2TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110009394-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | GLAXO GROUP LIMITED (GB) | 2011-01-13 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009394-A1 | TRICYCLIC NITROGEN COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS | NRDC, NCL, NPM1 | KCNH2 3726/4885TOP2A 96/4885BCHE 919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.