Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18415511 | 0.90 | ALDH1A1 (0.61) | ALDH1A1LMNAMEN1MAPTCRHBP | |
| SCHEMBL18795896 | 0.83 | ALDH1A1 (0.70) | ALDH1A1GPR35LMNAMEN1MAPT | |
| SCHEMBL29035952 | 0.82 | ALDH1A1 (0.52) | ALDH1A1GPR35LMNAMEN1MAPT | |
| SCHEMBL22430520 | 0.79 | HPGD (0.51) | ALDH1A1LMNAMEN1KMT2AHPGD | |
| SCHEMBL11419363 | 0.76 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTRAPGEF4 | |
| SCHEMBL3729817 | 0.75 | ALDH1A1 (0.63) | ALDH1A1GPR35LMNAMEN1MAPT | |
| SCHEMBL23317645 | 0.74 | HTT (0.57) | ALDH1A1LMNAMAPTNPSR1L3MBTL1 | |
| SCHEMBL22430504 | 0.74 | KMT2A (0.44) | ALDH1A1LMNAMEN1MAPTKMT2A | |
| SCHEMBL22430551 | 0.74 | TSHR (0.57) | ALDH1A1LMNAMEN1MAPTKMT2A | |
| SCHEMBL25886916 | 0.74 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTHPGDPTPRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125103-A1 | DIKETOPIPERAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |