Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.82 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.60 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15189895 | 0.99 | MTOR (0.80) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL3719579 | 0.93 | MTOR (0.71) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL3723782 | 0.91 | MTOR (0.81) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL412940 | 0.90 | MTOR (1.00) | MTORPIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL1831687 | 0.89 | MTOR (0.98) | MTORPIK3CAPIK3CG | |
| SCHEMBL10112572 | 0.87 | MTOR (0.93) | MTORPIK3CAPIK3CD | |
| SCHEMBL7937487 | 0.87 | MTOR (0.73) | MTORPIK3CAPIK3CG | |
| SCHEMBL2632629 | 0.86 | MTOR (0.72) | MTORPIK3CA | |
| SCHEMBL15189772 | 0.86 | MTOR (0.62) | MTORPIK3CAPIK3CGPIK3CD | |
| SCHEMBL444090 | 0.86 | MTOR (0.62) | MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| EP-2318377-B1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH INC (US) | 2013-08-21 | — | — | EP | disclosed |