Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.62 |
| ▸ | AXL | P30530 | 7/20 | 0.56 |
| ▸ | EGFR | P00533 | 4/20 | 0.56 |
| ▸ | PLK4 | O00444 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 3/20 | 0.56 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.56 |
| ▸ | STK10 | O94804 | 3/20 | 0.56 |
| ▸ | FYN | P06241 | 3/20 | 0.56 |
| ▸ | YES1 | P07947 | 3/20 | 0.56 |
| ▸ | LYN | P07948 | 3/20 | 0.56 |
| ▸ | SRC | P12931 | 3/20 | 0.56 |
| ▸ | FER | P16591 | 3/20 | 0.56 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.56 |
| ▸ | CSK | P41240 | 3/20 | 0.56 |
| ▸ | ABL2 | P42684 | 3/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 3/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.56 |
| ▸ | STK4 | Q13043 | 3/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 3/20 | 0.56 |
| ▸ | TNK1 | Q13470 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372007 | 1.00 | MET (0.62) | METAXLEGFRPLK4AURKA | |
| SCHEMBL372302 | 0.94 | MET (0.63) | METAXLEGFRPLK4AURKA | |
| SCHEMBL2923405 | 0.94 | MET (0.63) | METAXLEGFRPLK4AURKA | |
| SCHEMBL371943 | 0.94 | MET (0.63) | METAXLEGFRPLK4AURKA | |
| SCHEMBL372158 | 0.94 | MET (0.63) | METAXLEGFRPLK4AURKA | |
| SCHEMBL371939 | 0.92 | MET (0.61) | METAXLEGFRPLK4AURKA | |
| SCHEMBL372271 | 0.92 | MET (0.61) | METAXLEGFRPLK4AURKA | |
| SCHEMBL371783 | 0.91 | FLT4 (0.52) | METAXLEGFRPLK4AURKA | |
| SCHEMBL371886 | 0.91 | MET (0.61) | METAXLEGFRPLK4AURKA | |
| SCHEMBL371898 | 0.90 | MET (0.59) | METAXLEGFRPLK4AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3329918-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2022-05-25 | — | — | EP | disclosed |
| EP-3329918-A2 | C-MET MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2018-06-06 | — | — | EP | disclosed |
| EP-2409704-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2017-09-20 | — | — | EP | disclosed |
| EP-2392565-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2014-03-19 | — | — | EP | disclosed |
| EP-2392564-B1 | c-Met modulators and methods of use | EXELIXIS INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-2612853-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2013-07-10 | — | — | EP | disclosed |
| EP-2409704-A2 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2012-01-25 | — | — | EP | disclosed |
| EP-2392565-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-2392564-A1 | c-Met modulators and methods of use | Exelixis Inc. (US) | 2011-12-07 | — | — | EP | disclosed |
| EP-1673085-B1 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2011-11-09 | — | — | EP | disclosed |
| EP-2210607-B1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | EXELIXIS INC (US) | 2011-08-17 | — | — | EP | disclosed |
| EP-2213661-B1 | c-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2011-07-20 | — | — | EP | disclosed |
| EP-2213661-A1 | c-Met Modulators and Methods of Use | Exelixis Inc. (US) | 2010-08-04 | — | — | EP | disclosed |
| EP-2210607-A1 | N-[3-fluoro-4-({6-(methyloxy)-7-[(3-piperidin-1-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide for the treatment of cancer | Exelixis Inc. (US) | 2010-07-28 | — | — | EP | disclosed |