Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | MTOR | P42345 | 14/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721187 | 0.78 | PIK3CD (0.56) | PIK3CDMTORPIK3CAPIK3R1TRPM8 | |
| SCHEMBL13828577 | 0.78 | PIK3CD (0.56) | PIK3CDMTORPIK3CAPIK3R1TRPM8 | |
| SCHEMBL3728432 | 0.76 | MTOR (0.70) | PIK3CDMTORPIK3CAPIK3CG | |
| SCHEMBL2148489 | 0.75 | MTOR (0.66) | PIK3CDMTORPIK3CAPIK3R1TRPM8 | |
| SCHEMBL2148705 | 0.75 | TRPM8 (0.77) | MTORTRPM8 | |
| SCHEMBL3721578 | 0.75 | TRPM8 (0.59) | PIK3CDMTORPIK3CAPIK3R1TRPM8 | |
| SCHEMBL2148594 | 0.75 | MTOR (0.65) | PIK3CDMTORPIK3CAPIK3R1TRPM8 | |
| SCHEMBL16912796 | 0.73 | PIK3CD (0.63) | PIK3CDMTORPIK3CAPIK3R1PIK3CG | |
| SCHEMBL3730126 | 0.73 | PIK3CD (0.51) | PIK3CDMTORPIK3CAPIK3R1TRPM8 | |
| SCHEMBL18156584 | 0.73 | PIK3CD (0.51) | PIK3CDMTORPIK3CAPIK3R1TRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |