Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 3/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 6/20 | 0.41 |
| ▸ | JAK3 | P52333 | 4/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718879 | 0.80 | PIK3CA (0.55) | PIK3CAPIK3CDMTORLMNAHTT | |
| SCHEMBL3725617 | 0.73 | PIK3CA (0.72) | PIK3CAPIK3CDPIK3R1PIK3CBMTOR | |
| SCHEMBL3802375 | 0.73 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3R1PIK3CBMTOR | |
| SCHEMBL15190258 | 0.73 | MTOR (0.55) | MTOR | |
| SCHEMBL2369139 | 0.71 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3R1PIK3CBMTOR | |
| SCHEMBL34464803 | 0.71 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3R1PIK3CBMTOR | |
| SCHEMBL2369350 | 0.71 | MTOR (0.70) | PIK3CAPIK3CDPIK3R1MTORJAK2 | |
| SCHEMBL10328307 | 0.70 | PIK3CA (0.76) | PIK3CAPIK3CDPIK3R1PIK3CBMTOR | |
| SCHEMBL4380259 | 0.70 | JAK2 (0.70) | JAK2JAK3JAK1HDAC3NCOR1 | |
| SCHEMBL2370404 | 0.69 | MTOR (0.59) | PIK3CAPIK3CDMTORJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |