Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.55 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.48 |
| ▸ | MTOR | P42345 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628431 | 0.82 | CYP1A2 (0.39) | PIK3CAPIK3CDMTORHSD17B10ALDH1A1 | |
| SCHEMBL3722381 | 0.80 | PIK3CA (0.50) | PIK3CAPIK3CDMTORHSD17B10ALDH1A1 | |
| SCHEMBL21914801 | 0.76 | PIK3CA (0.71) | PIK3CAPIK3CDAOC3MTORHSD17B10 | |
| SCHEMBL3727348 | 0.73 | PIK3CA (0.60) | PIK3CAPIK3CDAOC3MTORHSD17B10 | |
| SCHEMBL2369411 | 0.73 | PIK3CA (0.60) | PIK3CAPIK3CDAOC3MTORHSD17B10 | |
| SCHEMBL2369996 | 0.73 | PIK3CA (0.71) | PIK3CAPIK3CDAOC3MTORPIK3CG | |
| SCHEMBL3730124 | 0.72 | PIK3CA (0.77) | PIK3CAPIK3CDMTORMAPTPIK3CG | |
| SCHEMBL3721523 | 0.71 | PIK3CA (0.75) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2369790 | 0.71 | PIK3CA (0.78) | PIK3CAPIK3CDMTORPIK3CG | |
| SCHEMBL2370051 | 0.71 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |