Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 1/20 | 0.48 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21630503 | 0.81 | CD274 (0.47) | POLBMMP8MMP1MMP2MMP3 | |
| SCHEMBL3801279 | 0.80 | POLB (0.51) | POLBMMP8ALDH1A1HTTMMP12 | |
| SCHEMBL5394740 | 0.79 | TP53 (0.45) | POLBMMP8MMP1MMP2MMP3 | |
| SCHEMBL6368600 | 0.78 | CD274 (0.45) | POLBMMP8MMP1MMP2MMP3 | |
| SCHEMBL4521880 | 0.77 | POLB (0.65) | POLBTP53LMNA | |
| SCHEMBL6372653 | 0.76 | POLB (0.55) | POLBMMP8MMP1MMP2MMP3 | |
| SCHEMBL7066497 | 0.76 | ITGB1 (0.56) | POLBMMP8MMP1MMP2MMP3 | |
| SCHEMBL27326120 | 0.76 | SMYD3 (0.52) | POLBMMP8MMP1MMP2MMP3 | |
| SCHEMBL27331234 | 0.76 | SMYD3 (0.52) | POLBMMP8MMP1MMP2MMP3 | |
| SCHEMBL13037001 | 0.75 | PSEN1 (0.52) | POLBTP53ALDH1A1CD274LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | claimed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | claimed |
| US-8614201-B2 | Heterocyclic amides as modulators of TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2013-12-24 | — | — | US | disclosed |
| WO-2010141805-A1 | HETEROCYCLIC AMIDES AS MODULATORS OF TRPA1 | JANSSEN PHARMACEUTICA NV (BE) | 2010-12-09 | — | — | WO | disclosed |