Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713929 | 0.92 | HIF1A (0.41) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL13187785 | 0.90 | HIF1A (0.45) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL3718827 | 0.87 | HIF1A (0.42) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL3715055 | 0.85 | HIF1A (0.43) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL3711870 | 0.85 | HRH3 (0.44) | HIF1AEPAS1HRH3 | |
| SCHEMBL13187713 | 0.83 | HDAC1 (0.44) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL13187709 | 0.80 | HDAC1 (0.53) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL3709590 | 0.77 | HIF1A (0.43) | HIF1AEPAS1HRH3 | |
| SCHEMBL13188444 | 0.77 | HIF1A (0.46) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL13188518 | 0.74 | ABL1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |