Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | RAF1 | P04049 | 2/20 | 0.38 |
| ▸ | LYN | P07948 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3718827 | 0.91 | HIF1A (0.42) | HIF1AEPAS1HRH3MAPK14HDAC3 | |
| SCHEMBL3711870 | 0.88 | HRH3 (0.44) | HIF1AEPAS1HRH3 | |
| SCHEMBL3722778 | 0.85 | HIF1A (0.42) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL3713929 | 0.83 | HIF1A (0.41) | HIF1AEPAS1HRH3MAPK14HDAC3 | |
| SCHEMBL13187713 | 0.82 | HDAC1 (0.44) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL13188444 | 0.81 | HIF1A (0.46) | HIF1AEPAS1HRH3MAPK14ABL1 | |
| SCHEMBL13187709 | 0.79 | HDAC1 (0.53) | HIF1AEPAS1HRH3HDAC3HDAC1 | |
| SCHEMBL3715178 | 0.78 | KMT2A (0.49) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3709590 | 0.76 | HIF1A (0.43) | HIF1AEPAS1HRH3MAPK14ABL1 | |
| SCHEMBL13187785 | 0.74 | HIF1A (0.45) | HIF1AEPAS1HRH3MAPK14ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |
| WO-2010100475-A1 | HYDROXAMIC ACID DERIVATIVES AS GRAM-NEGATIVE ANTIBACTERIAL AGENTS | ASTRAZENECA AB (SE) | 2010-09-10 | — | — | WO | disclosed |