Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.70 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.55 |
| ▸ | MBNL1 | Q9NR56 | 1/20 | 0.50 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.47 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2125225 | 0.83 | PDE10A (1.00) | PDE10AMBNL1PDK1ALDH1A1MEN1 | |
| SCHEMBL27610987 | 0.81 | PDE10A (0.96) | PDE10AMBNL1PDK1ALDH1A1MEN1 | |
| SCHEMBL30999690 | 0.81 | PDE10A (0.96) | PDE10AMBNL1PDK1ALDH1A1MEN1 | |
| SCHEMBL6858227 | 0.81 | PDE10A (0.96) | PDE10AMBNL1PDK1ALDH1A1MEN1 | |
| SCHEMBL29796545 | 0.81 | CYP2A6 (0.55) | PDE10ACYP2A6RAD51LCKCYP11B1 | |
| SCHEMBL17942777 | 0.81 | CYP2A6 (0.55) | PDE10ACYP2A6RAD51LCKCYP11B1 | |
| SCHEMBL4260071 | 0.80 | PDGFRB (0.55) | PDE10ACYP2A6RAD51CYP11B1CYP19A1 | |
| SCHEMBL2598835 | 0.80 | CYP2A6 (0.51) | PDE10ACYP2A6RAD51LCKCYP11B1 | |
| SCHEMBL2598827 | 0.80 | CYP2A6 (0.51) | PDE10ACYP2A6RAD51LCKNPY5R | |
| SCHEMBL14341086 | 0.80 | PDE10A (0.93) | PDE10AMBNL1PDK1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231663-A2 | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE AS C-MET INHIBITORS | Amgen, Inc (US) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009091374-A2 | FUSED HETEROCYCLIC DERIVATIVES AND METHODS OF USE | AMGEN INC. (US) | 2009-07-23 | — | — | WO | disclosed |