Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 2/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | RAD51 | Q06609 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31529366 | 0.84 | L3MBTL1 (0.61) | PDGFRBPDGFRAALDH1A1HPGDTLR8 | |
| SCHEMBL10641295 | 0.84 | L3MBTL1 (0.61) | PDGFRBPDGFRAALDH1A1HPGDTLR8 | |
| SCHEMBL3896885 | 0.83 | PDGFRB (0.50) | PDGFRBPDGFRAPDE10A | |
| SCHEMBL9590284 | 0.81 | TLR8 (0.67) | PDGFRBPDGFRAALDH1A1HPGDTLR8 | |
| Hydrochloric Acid SCHEMBL9847504 | 0.80 | L3MBTL1 (0.60) | PDGFRBPDGFRAALDH1A1HPGDTLR8 | |
| SCHEMBL3722967 | 0.80 | PDE10A (0.70) | CYP2A6ALDH1A1HPGDMEN1MAPT | |
| SCHEMBL4260073 | 0.78 | ALDH1A1 (0.73) | CYP2A6ALDH1A1HPGDMEN1GAA | |
| SCHEMBL17942777 | 0.77 | CYP2A6 (0.55) | CYP2A6ALDH1A1HPGDMEN1MAPT | |
| SCHEMBL4506402 | 0.77 | CYP11B1 (0.60) | PDGFRBPDGFRAMAPTPDE10ANPC1 | |
| SCHEMBL15958620 | 0.77 | ALDH1A1 (0.51) | PDGFRBPDGFRACYP2A6ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081931-A2 | FUSED HETEROCYCLIC DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR | Amgen Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008008539-A2 | FUSED HETEROCYCLIC DERIVATIVES USEFUL AS INHIBITORS OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR | AMGEN INC. (US) | 2008-01-17 | — | — | WO | disclosed |