Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 3/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 4/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2694843 | 0.94 | HRH3 (0.33) | CHRM2CHRM4CHRM1CHRM5CHRM3 | |
| SCHEMBL2695536 | 0.85 | SMN1; SMN2 (0.41) | CHRM2CHRM4CHRM1CHRM5CHRM3 | |
| SCHEMBL17075144 | 0.82 | KDM2B (0.31) | — | |
| SCHEMBL737934 | 0.80 | — | — | |
| SCHEMBL18587718 | 0.78 | CHRM2 (0.33) | CHRM2CHRM4CHRM1L3MBTL3L3MBTL1 | |
| SCHEMBL16877830 | 0.78 | — | — | |
| SCHEMBL735446 | 0.76 | SLC18A3 (0.35) | KCNH2L3MBTL3L3MBTL1HRH3 | |
| SCHEMBL736888 | 0.76 | — | — | |
| SCHEMBL4537249 | 0.75 | ALDH1A1 (0.37) | L3MBTL3L3MBTL1SMN1; SMN2 | |
| SCHEMBL2006246 | 0.74 | SLC18A3 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240458-A1 | ARYL SULFONAMIDES AS EFFECTIVE ANALGESICS | Boehringer Ingelheim International GmbH (DE) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009098051-A1 | ARYL SULFONAMIDES AS EFFECTIVE ANALGESICS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-08-13 | — | — | WO | disclosed |