Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | CKS1B | P61024 | 2/20 | 0.44 |
| ▸ | SKP1 | P63208 | 2/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.40 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717407 | 0.89 | CKS1B (0.53) | KITCKS1BSKP1SKP2JAK1 | |
| SCHEMBL3739355 | 0.79 | JAK1 (0.42) | KITCKS1BSKP1SKP2JAK1 | |
| SCHEMBL3724866 | 0.78 | JAK1 (0.52) | KITCKS1BSKP1SKP2MAPK1 | |
| SCHEMBL3725787 | 0.77 | JAK1 (0.51) | KITCKS1BSKP1SKP2MAPK1 | |
| SCHEMBL3716316 | 0.77 | JAK1 (0.45) | KITCKS1BSKP1SKP2MAPK1 | |
| SCHEMBL3729051 | 0.76 | JAK1 (0.56) | KITCKS1BSKP1SKP2MAPK1 | |
| SCHEMBL3717739 | 0.76 | CKS1B (0.50) | KITCKS1BSKP1SKP2ALK | |
| SCHEMBL3739352 | 0.75 | JAK1 (0.44) | KITCKS1BSKP1SKP2MAPK1 | |
| SCHEMBL3662967 | 0.74 | CHEK1 (0.55) | CKS1BSKP1SKP2CCNCCDK8 | |
| SCHEMBL3721916 | 0.73 | PIK3CD (0.56) | KITCKS1BSKP1SKP2CCNK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242757-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2010-10-27 | — | — | EP | disclosed |
| WO-2009089359-A1 | PYRAZOLOPYRIDINES AS KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2009-07-16 | — | — | WO | disclosed |