Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.74 |
| ▸ | PIK3CA | P42336 | 17/20 | 0.74 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725847 | 0.88 | MTOR (0.69) | MTORPIK3CAPIK3CG | |
| SCHEMBL32459 | 0.85 | PIK3CA (1.00) | MTORPIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL1409209 | 0.84 | PIK3CA (1.00) | MTORPIK3CAPIK3CG | |
| SCHEMBL32231 | 0.84 | PIK3CA (0.89) | MTORPIK3CAPIK3CG | |
| SCHEMBL3989252 | 0.83 | MTOR (0.70) | MTORPIK3CAPIK3CG | |
| SCHEMBL4239087 | 0.83 | MTOR (0.70) | MTORPIK3CAPIK3CG | |
| SCHEMBL32241 | 0.83 | PIK3CA (0.94) | MTORPIK3CAPIK3CG | |
| SCHEMBL32368 | 0.83 | PIK3CA (0.94) | MTORPIK3CAPIK3CG | |
| SCHEMBL32706 | 0.83 | PIK3CA (0.91) | MTORPIK3CAPIK3CG | |
| SCHEMBL3428530 | 0.82 | PIK3CA (0.69) | MTORPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | claimed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |