Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.70 |
| ▸ | PIK3CA | P42336 | 16/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4241641 | 0.90 | PIK3CA (0.69) | MTORPIK3CAPIK3CG | |
| SCHEMBL3989252 | 0.84 | MTOR (0.70) | MTORPIK3CAPIK3CG | |
| SCHEMBL3998917 | 0.83 | PIK3CA (0.66) | MTORPIK3CAPIK3CG | |
| SCHEMBL4121632 | 0.83 | MTOR (0.64) | MTORPIK3CAPIK3CG | |
| SCHEMBL3723258 | 0.83 | MTOR (0.74) | MTORPIK3CAPIK3CG | |
| SCHEMBL32459 | 0.82 | PIK3CA (1.00) | MTORPIK3CAPIK3CG | |
| SCHEMBL3991923 | 0.82 | MTOR (0.71) | MTORPIK3CAPIK3CG | |
| Hydrochloric Acid SCHEMBL1409209 | 0.82 | PIK3CA (1.00) | MTORPIK3CAPIK3CG | |
| SCHEMBL3428530 | 0.81 | PIK3CA (0.69) | MTORPIK3CAPIK3CG | |
| SCHEMBL2729678 | 0.81 | MTOR (0.66) | MTORPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | WYETH (US) | 2009-06-11 | — | — | US | claimed |
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | WYETH (US) | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149458-A1 | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS | MTOR, PIK3CA, PIK3CD | MTOR 1/4885PIK3CA 2/4885PIK3CG 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.