Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 14/20 | 0.57 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.51 |
| ▸ | CDC7 | O00311 | 2/20 | 0.51 |
| ▸ | PLK4 | O00444 | 2/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | PRKX | P51817 | 2/20 | 0.51 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.51 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.51 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.51 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9091165 | 0.74 | PLK1 (0.59) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL3717871 | 0.73 | CXCR2 (0.58) | PLK1CXCR1CXCR2 | |
| SCHEMBL10094130 | 0.71 | BLM (0.45) | CXCR1CXCR2AURKAAURKB | |
| SCHEMBL7345496 | 0.71 | PLK1 (0.57) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL20033714 | 0.70 | BLM (0.44) | GSK3AGSK3BCXCR1CXCR2AURKA | |
| SCHEMBL12262562 | 0.69 | CXCR2 (0.78) | CXCR1CXCR2CCR6 | |
| SCHEMBL12086675 | 0.69 | CXCR2 (0.78) | CXCR1CXCR2CCR6 | |
| SCHEMBL12262866 | 0.69 | CXCR2 (0.67) | PLK1CXCR1CXCR2CCR6 | |
| SCHEMBL4376049 | 0.68 | PLK1 (1.00) | PLK1CHEK1CDC7PLK4DAPK3 | |
| SCHEMBL4376047 | 0.68 | PLK1 (1.00) | PLK1CHEK1CDC7PLK4DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010131146-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | claimed |
| WO-2010131146-A1 | CYCLOBUTENEDIONE DERIVATIVES | PFIZER LIMITED (GB) | 2010-11-18 | — | — | WO | disclosed |