Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2489301 | 0.82 | RAB9A (0.50) | NOTUMRAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL17922502 | 0.81 | NOTUM (0.47) | NOTUMRAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL2900829 | 0.80 | NOTUM (0.68) | NOTUMRAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL2967412 | 0.80 | RAB9A (0.42) | NOTUMRAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL5559631 | 0.79 | POLB (0.46) | NOTUMRAB9AALDH1A1NPC1TP53 | |
| SCHEMBL2898686 | 0.78 | NOTUM (0.42) | NOTUMRAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL3955619 | 0.78 | NOTUM (0.51) | NOTUMRAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL4104166 | 0.78 | RAB9A (0.46) | NOTUMRAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL4048480 | 0.75 | MEN1 (0.39) | NOTUMRAB9ASMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL6195151 | 0.74 | NPC1 (0.41) | RAB9ASMN1; SMN2TDP1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010123451-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2010-10-28 | — | — | WO | claimed |
| WO-2010123451-A1 | SULPHIDE BRIDGED DERIVATIVES AS MODULATORS OF MGLUR5 | ASTRAZENECA AB (SE) | 2010-10-28 | — | — | WO | disclosed |