Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3719268 | 0.86 | TSHR (0.46) | ALDH1A1TMEM97SIGMAR1 | |
| SCHEMBL16102788 | 0.84 | CYP3A4 (0.60) | OPRM1OPRD1OPRK1ALDH1A1SIGMAR1 | |
| SCHEMBL18458294 | 0.82 | KCNA3 (0.58) | OPRM1OPRD1OPRK1ALDH1A1 | |
| SCHEMBL3724255 | 0.81 | DDB1 (0.48) | — | |
| SCHEMBL25554839 | 0.81 | TSHR (0.49) | — | |
| SCHEMBL25793979 | 0.80 | OPRM1 (0.54) | OPRM1OPRD1OPRK1ALDH1A1HSD11B1 | |
| SCHEMBL3718049 | 0.79 | MEN1 (0.48) | OPRD1OPRK1MEN1NPC1KMT2A | |
| SCHEMBL21876539 | 0.77 | SMN1; SMN2 (0.54) | OPRD1OPRK1MEN1NPC1KMT2A | |
| SCHEMBL10243152 | 0.76 | MEN1 (0.62) | ALDH1A1HSD11B1CHRM1TMEM97SIGMAR1 | |
| SCHEMBL29239819 | 0.76 | TSHR (0.53) | OPRM1ALDH1A1SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010136778-A1 | DIBENZOTHIOPHENE DERIVATIVES AS DNA- PK INHIBITORS | KUDOS PHARMACEUTICALS LIMITED (GB) | 2010-12-02 | — | — | WO | disclosed |