SCHEMBL3724843

SCHEMBL3724843

FC(F)(F)c1nnc(Cl)o1

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
EPHX2 P34913 1/20 0.38
HDAC6 Q9UBN7 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1829308 0.80 EPHX2 (0.45) EPHX2HDAC6
SCHEMBL18760057 0.72 HDAC6 (0.47) EPHX2HDAC6
SCHEMBL725711 0.69 ALDH1A1 (0.38) EPHX2HDAC6
SCHEMBL12976224 0.68 EPHX2 (0.38) EPHX2HDAC6
SCHEMBL10202700 0.68 EPHX2 (0.38) EPHX2HDAC6
SCHEMBL2879549 0.68 EPHX2 (0.38) EPHX2HDAC6
SCHEMBL16215584 0.68 EPHX2 (0.38) EPHX2HDAC6
SCHEMBL22116888 0.66 NPC1 (0.59) HDAC6
SCHEMBL7885449 0.66 EPHX2 (0.33) EPHX2HDAC6
SCHEMBL6823997 0.66 EPHX2 (0.33) EPHX2HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010122578-A2 PROCESS FOR THE PREPARATION OF SITAGLIPTIN AND ITS INTERMEDIATES MSN LABORATORIES LIMITED (IN) 2010-10-28 WO disclosed