Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 5/20 | 0.35 |
| ▸ | ATAD2 | Q6PL18 | 4/20 | 0.35 |
| ▸ | VCP | P55072 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
| ▸ | HPGDS | O60760 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995214 | 0.89 | KIT (0.42) | KITVCPBACE1LMNANPSR1 | |
| SCHEMBL3723438 | 0.86 | KIT (0.39) | KITVCPLMNANPSR1TSHR | |
| SCHEMBL3724914 | 0.84 | KIT (0.48) | KITBRD4VCPBACE1PIM1 | |
| SCHEMBL2995216 | 0.80 | KIT (0.52) | KITBRD4VCPBACE1PIM1 | |
| SCHEMBL3723439 | 0.77 | KIT (0.49) | KITBRD4VCPBACE1PIM1 | |
| SCHEMBL2999762 | 0.77 | BRD4 (0.48) | BRD4ATAD2CHEK1KCNH2KHK | |
| Hydrochloric Acid SCHEMBL3415428 | 0.76 | BRD4 (0.47) | BRD4ATAD2CHEK1KCNH2KHK | |
| SCHEMBL3109553 | 0.72 | NPY5R (0.44) | BRD4ATAD2CHEK1KCNH2KHK | |
| SCHEMBL3000216 | 0.71 | NPY5R (0.50) | BRD4CHEK1KCNH2BACE1PIM1 | |
| SCHEMBL3005991 | 0.69 | CHEK1 (0.40) | VCPCHEK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178870-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025478-A1 | INDOLE AND INDAZOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |