Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13260951 | 0.83 | KDM4E (0.40) | KDM4ESMN1; SMN2KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL3721607 | 0.79 | KDM4E (0.43) | KDM4ESMN1; SMN2KMT2AALDH1A1TDP1 | |
| SCHEMBL13260970 | 0.77 | POLQ (0.48) | KDM4ESMN1; SMN2KMT2AHPGDL3MBTL1 | |
| SCHEMBL3731303 | 0.74 | PTGS1 (0.39) | SMN1; SMN2KMT2AALDH1A1PKMHSD17B10 | |
| SCHEMBL3724391 | 0.72 | HDAC1 (0.42) | KDM4ESMN1; SMN2KMT2AALDH1A1TDP1 | |
| SCHEMBL13088493 | 0.70 | HPGD (0.68) | KDM4ESMN1; SMN2KMT2AALDH1A1TDP1 | |
| SCHEMBL13260110 | 0.69 | KDM4E (0.43) | KDM4ESMN1; SMN2KMT2AALDH1A1TDP1 | |
| SCHEMBL14343501 | 0.69 | ALDH1A1 (0.47) | KDM4ESMN1; SMN2KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL15176566 | 0.68 | SMN1; SMN2 (0.60) | KDM4ESMN1; SMN2KMT2ACYP1A2ALDH1A1 | |
| SCHEMBL25236370 | 0.68 | TSHR (0.65) | KDM4ESMN1; SMN2ALDH1A1PKMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |
| WO-2010093885-A1 | INHIBITORS OF AKT ACTIVITY | GLAXOSMITHKLINE LLC (US) | 2010-08-19 | — | — | WO | disclosed |