Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.55 |
| ▸ | PIK3R1 | P27986 | 16/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15603144 | 0.87 | PIK3CA (0.57) | PIK3CAPIK3R1PIK3CDKCNH2PIK3CB | |
| SCHEMBL3725448 | 0.86 | PIK3R1 (0.74) | PIK3CAPIK3R1PIK3CDKCNH2 | |
| SCHEMBL5558592 | 0.85 | PIK3R1 (0.75) | PIK3CAPIK3R1PIK3CDKCNH2PIK3CB | |
| SCHEMBL20458875 | 0.85 | PIK3CA (0.57) | PIK3CAPIK3R1PIK3CDKCNH2PIK3CB | |
| SCHEMBL632497 | 0.78 | PIK3R1 (0.74) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL633416 | 0.77 | PIK3CA (0.74) | PIK3CAPIK3R1PIK3CDKCNH2 | |
| SCHEMBL15603045 | 0.76 | PIK3CA (0.57) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL632841 | 0.75 | PIK3R1 (0.72) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL893447 | 0.75 | PIK3CA (0.71) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG | |
| SCHEMBL633055 | 0.75 | PIK3R1 (0.53) | PIK3CAPIK3R1PIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010119264-A1 | IMIDAZOPYRAZINES FOR USE AS KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCÓLOGICAS (CNIO) (ES) | 2010-10-21 | — | — | WO | disclosed |