Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.68 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.65 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.65 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.65 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.65 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3795978 | 0.94 | MTOR (0.65) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3721618 | 0.94 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3729716 | 0.90 | MTOR (0.55) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3718679 | 0.89 | MTOR (0.59) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3725356 | 0.84 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3719933 | 0.84 | MTOR (0.69) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3722987 | 0.83 | MTOR (0.60) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL1830352 | 0.81 | MTOR (1.00) | MTORPIK3CA | |
| Gedatolisib SCHEMBL20765154 | 0.81 | MTOR (0.93) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL13828809 | 0.81 | MTOR (0.81) | MTORPIK3CAPIK3CGPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120996-A1 | 5,6,7,8-TETRAHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |