Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.69 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.69 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.69 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.69 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.69 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725356 | 0.95 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3795978 | 0.85 | MTOR (0.65) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL18431650 | 0.84 | MTOR (0.66) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3722933 | 0.84 | MTOR (0.55) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3725520 | 0.84 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3796880 | 0.83 | MTOR (0.67) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3721618 | 0.83 | MTOR (0.68) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL13828809 | 0.83 | MTOR (0.81) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3721950 | 0.83 | MTOR (0.57) | MTORPIK3CAPIK3CGPIK3CBPIK3CD | |
| SCHEMBL3720834 | 0.83 | MTOR (0.61) | MTORPIK3CAPIK3CGPIK3CBPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120991-A1 | 5, 6, 7, 8-TETRAHYDROPYRIDO[4,3-D]PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR, PI3, AND HSMG-1 KINASE INHIBITORS, AND THEIR SYNTHESES | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |