Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 5/20 | 0.52 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725521 | 1.00 | CNR1 (0.52) | CNR1CNR2EPHX2FAAHTRPV1 | |
| SCHEMBL3725125 | 0.86 | CNR1 (0.45) | CNR1CNR2EPHX2MEN1KMT2A | |
| SCHEMBL675634 | 0.86 | CNR1 (0.52) | CNR1CNR2EPHX2FAAHTRPV1 | |
| SCHEMBL675635 | 0.86 | CNR1 (0.52) | CNR1CNR2EPHX2FAAHTRPV1 | |
| SCHEMBL676230 | 0.85 | CNR1 (0.51) | CNR1CNR2EPHX2FAAHTRPV1 | |
| SCHEMBL676231 | 0.85 | CNR1 (0.51) | CNR1CNR2EPHX2FAAHTRPV1 | |
| SCHEMBL676314 | 0.83 | KMT2A (0.48) | CNR1MEN1KMT2ATP53CYP3A4 | |
| SCHEMBL3424526 | 0.83 | TBXAS1 (0.36) | CNR1CNR2MEN1KMT2ATP53 | |
| SCHEMBL3424523 | 0.83 | TBXAS1 (0.36) | CNR1CNR2MEN1KMT2ATP53 | |
| SCHEMBL3727408 | 0.81 | MEN1 (0.41) | CNR1CNR2MEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8895744-B2 | Alfa-carboline inhibitors of NPM-ALK, RET, and Bcr-Abl | UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA (IT) | 2014-11-25 | — | — | US | disclosed |
| CN-102203092-A | Alfa-carboline inhibitors of npm-alk, ret, and bcr-abl | UNIV DEGLI STUDI MILANO | 2011-09-28 | — | — | CN | disclosed |
| EP-2161271-A1 | Alpha-carboline inhibitors of NMP-ALK, RET, and Bcr-Abl | Università Degli Studi Di Milano - Bicocca (IT) | 2010-03-10 | — | — | EP | disclosed |