Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD5 | P21918 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5463193 | 0.87 | TDP1 (0.63) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL30726450 | 0.86 | DRD1 (0.56) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL1853220 | 0.85 | DRD1 (0.62) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL13744516 | 0.84 | SMN1; SMN2 (0.66) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL2011534 | 0.84 | CYP2D6 (0.60) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL25374902 | 0.83 | KDM4E (0.57) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL28937449 | 0.83 | POLB (0.64) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL29559230 | 0.83 | POLB (0.64) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL1953267 | 0.83 | TSHR (0.56) | SMN1; SMN2POLBDRD1DRD4DRD5 | |
| SCHEMBL5235337 | 0.82 | DRD1 (0.52) | SMN1; SMN2POLBDRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010125103-A1 | DIKETOPIPERAZINE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-11-04 | — | — | WO | disclosed |