Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | LTA4H | P09960 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HRH1 | P35367 | 3/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | DRD4 | P21917 | 2/20 | 0.50 |
| ▸ | DRD5 | P21918 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3725632 | 0.87 | SMN1; SMN2 (0.64) | POLBCYP2D6TSHRSMN1; SMN2HTR1A | |
| SCHEMBL14410108 | 0.84 | TDP1 (0.77) | TDP1POLBCYP2D6CYP2C19CYP1A2 | |
| SCHEMBL30150794 | 0.84 | LTA4H (0.73) | TDP1LTA4HPOLBCYP2D6CYP2C19 | |
| SCHEMBL1031593 | 0.84 | LTA4H (0.73) | TDP1LTA4HPOLBCYP2D6CYP2C19 | |
| SCHEMBL1027777 | 0.83 | LTA4H (0.71) | TDP1LTA4HPOLBCYP2D6CYP2C19 | |
| SCHEMBL12586924 | 0.82 | ALDH1A1 (0.62) | TDP1LTA4HPOLBCYP2D6CYP2C19 | |
| SCHEMBL13744815 | 0.82 | POLB (0.70) | TDP1LTA4HPOLBCYP2D6CYP2C19 | |
| SCHEMBL30670120 | 0.81 | TDP1 (0.61) | TDP1POLBCYP2D6CYP2C19CYP1A2 | |
| SCHEMBL8264564 | 0.78 | TDP1 (1.00) | TDP1POLBCYP2D6CYP2C19CYP1A2 | |
| SCHEMBL24445406 | 0.77 | CYP2D6 (0.68) | TDP1CYP2D6CYP2C19CYP1A2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20070161677-A1 | Bisarylurea derivatives | MERCK PATENT GMBH (DE) | 2007-07-12 | — | — | US | disclosed |
| US-20070054888-A1 | NOVEL SUBSTITUTED DIAMINE DERIVATIVES USEFUL AS MOTILIN AGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2007-03-08 | — | — | US | disclosed |
| US-7166601-B2 | Substituted diamine derivatives useful as motilin antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2007-01-23 | — | — | US | disclosed |
| US-7112586-B2 | Substituted diamine derivatives useful as motilin antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2006-09-26 | — | — | US | disclosed |
| US-20060183741-A1 | Treatment of associated conditions and disorders such as gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel syndrome | JOHNSON SIGMOND G | 2006-08-17 | — | — | US | disclosed |
| US-6967199-B2 | Substituted diamine derivatives useful as motilin antagonists | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2005-11-22 | — | — | US | disclosed |
| US-20050148584-A1 | Novel substituted diamine derivatives useful as motilin antagonists | JOHNSON SIGMOND G (US) | 2005-07-07 | — | — | US | disclosed |
| US-20030203906-A1 | A phenylamide derivatives for treating gastrointestinal reflux disorders, eating disorder obesity and irritable bowel disorder | JOHNSON SIGMONG G (US) | 2003-10-30 | — | — | US | disclosed |
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | disclosed |
| US-6511980-B2 | For therapy of gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel disorder | ORTHO MCNEIL PHARMACEUTICAL, INC. | 2003-01-28 | — | — | US | disclosed |
| US-20020013352-A1 | For therapy of gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel disorder | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2002-01-31 | — | — | US | disclosed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161677-A1 | Bisarylurea derivatives | BRAF, RAF1, NRAS | TDP1 835/4885LTA4H 4652/4885POLB 919/4885 |
| US-20070054888-A1 | NOVEL SUBSTITUTED DIAMINE DERIVATIVES USEFUL AS MOTILIN AGONISTS | MLNR, NPY4R, GIPR | TDP1 3352/4885LTA4H 1811/4885POLB 4322/4885 |
| US-20020013352-A1 | For therapy of gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel disorder | MLNR, GIPR, NPY1R | TDP1 3553/4885LTA4H 2264/4885POLB 4511/4885 |
| US-20060183741-A1 | Treatment of associated conditions and disorders such as gastrointestinal reflux disorders, eating disorders leading to obesity and irritable bowel syndrome | MLNR, NPY4R, GIPR | TDP1 3743/4885LTA4H 1628/4885POLB 4518/4885 |
| US-20030203906-A1 | A phenylamide derivatives for treating gastrointestinal reflux disorders, eating disorder obesity and irritable bowel disorder | MLNR, GIPR, NPY1R | TDP1 3434/4885LTA4H 2663/4885POLB 4504/4885 |
| US-20050148584-A1 | Novel substituted diamine derivatives useful as motilin antagonists | MLNR, NPY4R, GIPR | TDP1 3578/4885LTA4H 2168/4885POLB 4251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.