Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 11/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | BLK | P51451 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3025855 | 0.84 | KDM4C (0.41) | KDM4CKCNH2 | |
| SCHEMBL3008846 | 0.84 | HTR6 (0.41) | KCNH2ALDH1A1CYP1A2CLK4CYP2C19 | |
| Hydrochloric Acid SCHEMBL3016388 | 0.83 | HTR6 (0.41) | KCNH2ALDH1A1CYP1A2CLK4CYP2C19 | |
| SCHEMBL3725917 | 0.79 | FLT3 (0.35) | KCNH2ALDH1A1CYP1A2CLK4CYP2C19 | |
| SCHEMBL3016117 | 0.74 | KCNH2 (0.52) | KCNH2 | |
| Hydrochloric Acid SCHEMBL3022236 | 0.74 | KCNH2 (0.51) | KCNH2 | |
| SCHEMBL3029093 | 0.73 | KCNH2 (0.42) | KDM4CKCNH2 | |
| Hydrochloric Acid SCHEMBL3027523 | 0.72 | KCNH2 (0.42) | KDM4CKCNH2 | |
| SCHEMBL3025404 | 0.72 | KDM4C (0.40) | KDM4CKDM6B | |
| SCHEMBL3025294 | 0.71 | KCNH2 (0.46) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139898-A1 | COMPOUNDS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008128961-A1 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |