Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | SPR | P35270 | 2/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3727605 | 0.83 | HTR2A (0.39) | HTR2AHTR2CHRH1HTR2BSMN1; SMN2 | |
| SCHEMBL13048440 | 0.83 | HTR2A (0.39) | HTR2AHTR2CHRH1HTR2BSMN1; SMN2 | |
| SCHEMBL3729119 | 0.72 | HRH1 (0.44) | HTR2AHTR2CHRH1HTR2BCYP1A2 | |
| SCHEMBL3733142 | 0.71 | RXFP1 (0.41) | HTR2AHTR2CHRH1HTR2BSMN1; SMN2 | |
| SCHEMBL14034394 | 0.66 | HTR2A (0.41) | HTR2AKDM4EHPGDALDH1A1RAB9A | |
| SCHEMBL31392781 | 0.65 | CYP1A2 (0.67) | KDM4EHPGDALDH1A1CYP1A2BCHE | |
| SCHEMBL14441607 | 0.65 | CYP1A2 (0.67) | KDM4EHPGDALDH1A1CYP1A2BCHE | |
| SCHEMBL3731888 | 0.64 | HTR2A (0.43) | HTR2AHTR2CHRH1HTR2BSMN1; SMN2 | |
| SCHEMBL3733684 | 0.64 | HTR2A (0.39) | HTR2AHTR2CHRH1HTR2BSMN1; SMN2 | |
| SCHEMBL12604459 | 0.62 | ALDH1A1 (0.50) | SMN1; SMN2KDM4EHPGDALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010142652-A1 | IMIDAZOBENZAZEPINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISEASES | GLAXO GROUP LIMITED (GB) | 2010-12-16 | — | — | WO | disclosed |
| WO-2010142652-A1 | IMIDAZOBENZAZEPINE COMPOUNDS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM (CNS) DISEASES | GLAXO GROUP LIMITED (GB) | 2010-12-16 | — | — | WO | disclosed |