Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3713282 | 0.82 | SLC6A4 (0.43) | SLC6A4SMN1; SMN2 | |
| SCHEMBL2505581 | 0.79 | SMN1; SMN2 (0.43) | SLC6A4CSNK2A1GLASMN1; SMN2TTR | |
| SCHEMBL3719560 | 0.78 | SLC6A4 (0.31) | SLC6A4 | |
| SCHEMBL3711085 | 0.77 | SLC6A4 (0.35) | SLC6A4SMN1; SMN2 | |
| SCHEMBL2406028 | 0.76 | SLC6A4 (0.57) | SLC6A4TTR | |
| SCHEMBL3726543 | 0.74 | SLC6A4 (0.37) | SLC6A4TTR | |
| SCHEMBL2408767 | 0.74 | LMNA (0.41) | SLC6A4SMN1; SMN2TTR | |
| SCHEMBL924818 | 0.72 | SLC6A4 (0.39) | SLC6A4TTR | |
| SCHEMBL3726545 | 0.70 | SLC6A4 (0.35) | SLC6A4 | |
| SCHEMBL3726542 | 0.69 | SLC6A4 (0.34) | SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231677-A2 | TRISUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | Novartis AG (CH) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009074674-A2 | TRISUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-06-18 | — | — | WO | disclosed |