Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3208271 | 0.90 | BRD4 (0.39) | BRD4ATAD2PIM1PIM2 | |
| SCHEMBL3027155 | 0.81 | BRD4 (0.41) | BRD4ATAD2KDM4EGAAMAPT | |
| SCHEMBL27809786 | 0.81 | BRD4 (0.41) | BRD4ATAD2KDM4EGAAMAPT | |
| SCHEMBL1277663 | 0.77 | BRD4 (0.43) | BRD4ATAD2KDM4EGAAMAPT | |
| SCHEMBL1277660 | 0.77 | BRD4 (0.43) | BRD4ATAD2KDM4EGAAMAPT | |
| SCHEMBL3025267 | 0.77 | BRD4 (0.39) | BRD4ATAD2KDM4EGAAMAPT | |
| SCHEMBL27787909 | 0.77 | BRD4 (0.41) | BRD4ATAD2KDM4EGAAMAPT | |
| SCHEMBL3025264 | 0.77 | BRD4 (0.39) | BRD4ATAD2KDM4EGAAMAPT | |
| SCHEMBL2930374 | 0.77 | BRD4 (0.41) | BRD4ATAD2KDM4EGAAMAPT | |
| SCHEMBL1277833 | 0.76 | BRD4 (0.38) | BRD4ATAD2KDM4EGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178869-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG Life Sciences Ltd. (KR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009025477-A1 | INDOLE COMPOUNDS AS AN INHIBITOR OF CELLULAR NECROSIS | LG LIFE SCIENCES LTD. (KR) | 2009-02-26 | — | — | WO | disclosed |