Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KHK | P50053 | 2/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3670248 | 0.82 | HRH3 (0.65) | HRH3TP53THRBMAPTACSS2 | |
| SCHEMBL3670242 | 0.82 | HRH3 (0.65) | HRH3TP53THRBMAPTACSS2 | |
| SCHEMBL14000448 | 0.82 | HRH3 (0.65) | HRH3TP53THRBMAPTACSS2 | |
| SCHEMBL3732608 | 0.77 | MAPK1 (0.59) | HRH3THRB | |
| SCHEMBL4937782 | 0.74 | LMNA (0.54) | HRH3HTR4 | |
| SCHEMBL594263 | 0.72 | NPC1 (0.72) | HTR4 | |
| SCHEMBL3666585 | 0.72 | HRH3 (0.71) | HRH3 | |
| SCHEMBL3721358 | 0.72 | HRH3 (0.58) | HRH3TP53MAPTACSS2 | |
| SCHEMBL1948459 | 0.72 | DHODH (0.49) | HRH3TP53PDE4B | |
| Hydrochloric Acid SCHEMBL3674276 | 0.71 | HRH3 (0.70) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155719-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | Wyeth LLC (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008147945-A1 | AZACYCLYLBENZAMIDE DERIVATIVES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-12-04 | — | — | WO | disclosed |