Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | MMP13 | P45452 | 1/20 | 0.34 |
| ▸ | PGD | P52209 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL3744577 | 0.87 | SLC1A3 (0.46) | SLC1A3SLC1A2SLC1A1PDE4ATSHR | |
| SCHEMBL7290471 | 0.87 | SLC1A3 (0.54) | SLC1A3SLC1A2SLC1A1PDE4ATSHR | |
| SCHEMBL722389 | 0.87 | SLC1A3 (0.54) | SLC1A3SLC1A2SLC1A1PDE4ATSHR | |
| SCHEMBL7291825 | 0.87 | SLC1A3 (0.54) | SLC1A3SLC1A2SLC1A1PDE4ATSHR | |
| SCHEMBL3734202 | 0.84 | SLC1A3 (0.35) | SLC1A3SLC1A2SLC1A1TDP1PDE4A | |
| SCHEMBL27742181 | 0.84 | SLC1A3 (0.52) | SLC1A3SLC1A2SLC1A1PDE4ATSHR | |
| 1,4-Butanediol SCHEMBL3733977 | 0.83 | SLC1A3 (0.43) | SLC1A3SLC1A2SLC1A1PDE4ATSHR | |
| SCHEMBL3734318 | 0.82 | TDP1 (0.37) | SLC1A3SLC1A2SLC1A1TDP1PDE4A | |
| Di(Hydroxyethyl)Ether SCHEMBL3746401 | 0.80 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1PDE4ATSHR | |
| Propylene Glycol SCHEMBL3729380 | 0.80 | TDP1 (0.39) | TDP1PDE4ATSHROR51E2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |