Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.40 |
| ▸ | WNT1 | P04628 | 4/20 | 0.40 |
| ▸ | PIM1 | P11309 | 4/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL473715 | 1.00 | GSK3B (0.40) | GSK3BDYRK1AWNT1PIM1PIM3 | |
| SCHEMBL3727829 | 1.00 | GSK3B (0.40) | GSK3BDYRK1AWNT1PIM1PIM3 | |
| SCHEMBL3729496 | 1.00 | GSK3B (0.40) | GSK3BDYRK1AWNT1PIM1PIM3 | |
| SCHEMBL11908966 | 0.91 | CHRM1 (0.45) | GSK3BDYRK1ACHEK1ACHEUSP30 | |
| SCHEMBL11908116 | 0.90 | CHRM1 (0.41) | GSK3BDYRK1AWNT1PIM1PIM3 | |
| SCHEMBL11908405 | 0.86 | MARK3 (0.40) | GSK3BDYRK1APIM1CHEK1ACHE | |
| SCHEMBL3725345 | 0.85 | USP30 (0.38) | PIM1CHEK1ACHEUSP30CCNA2 | |
| SCHEMBL11909192 | 0.85 | CHEK1 (0.40) | GSK3BDYRK1ACHEK1ACHEUSP30 | |
| SCHEMBL11908188 | 0.83 | CHRM1 (0.41) | GSK3BDYRK1APIM1CHEK1ACHE | |
| SCHEMBL3722569 | 0.83 | CHRM1 (0.41) | GSK3BDYRK1APIM1CHEK1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010109084-A2 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-09-30 | — | — | WO | disclosed |