Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.37 |
| ▸ | AXL | P30530 | 8/20 | 0.37 |
| ▸ | MERTK | Q12866 | 8/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11908966 | 0.91 | CHRM1 (0.45) | CHEK1ACHEGSK3BDYRK1ACHRM1 | |
| SCHEMBL11929499 | 0.90 | CHRM1 (0.43) | CHEK1ACHEGSK3BDYRK1ACHRM1 | |
| SCHEMBL11908405 | 0.90 | MARK3 (0.40) | CHEK1ACHEGSK3BDYRK1ACHRM1 | |
| SCHEMBL11907420 | 0.90 | CHRM1 (0.43) | CHEK1ACHEGSK3BDYRK1ACHRM1 | |
| SCHEMBL11909678 | 0.89 | CHEK1 (0.41) | CHEK1ACHEGSK3BDYRK1ACHRM1 | |
| SCHEMBL11907618 | 0.86 | PIM1 (0.37) | — | |
| SCHEMBL473715 | 0.85 | GSK3B (0.40) | CHEK1ACHEGSK3BDYRK1ACHRM1 | |
| SCHEMBL3727024 | 0.85 | GSK3B (0.40) | CHEK1ACHEGSK3BDYRK1ACHRM1 | |
| SCHEMBL3727829 | 0.85 | GSK3B (0.40) | CHEK1ACHEGSK3BDYRK1ACHRM1 | |
| SCHEMBL3729496 | 0.85 | GSK3B (0.40) | CHEK1ACHEGSK3BDYRK1ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120208809-A1 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208809-A1 | 9H-PYRROLO[2,3-B: 5,4-C'] DIPYRIDINE AZACARBOLINE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | NPR3, CCNH, CBR3 | CHEK1 1152/4885ACHE 4455/4885GSK3B 3703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.