Gestodene

Gestodene

SCHEMBL37271

C#C[C@]1(O)C=C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21CC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PGR

The experimentally established mechanism targets of Gestodene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR known ✓ P06401 7/20 1.00
AR P10275 6/20 1.00
LMNA P02545 5/20 1.00
SLC6A4 P31645 4/20 1.00
ESR1 P03372 4/20 1.00
OPRM1 P35372 2/20 1.00
CYP3A4 P08684 5/20 0.66
ABCB11 O95342 4/20 0.66
SHBG P04278 4/20 0.66
MEN1 O00255 3/20 0.66
KMT2A Q03164 3/20 0.66
NR3C1 P04150 3/20 0.66
CYP2C19 P33261 3/20 0.66
POLB P06746 1/20 0.66
ALDH1A1 P00352 2/20 0.53
TSHR P16473 1/20 0.53
HIF1A Q16665 1/20 0.53
ADRA2A P08913 1/20 0.53
NR3C2 P08235 1/20 0.52
NR1I2 O75469 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Gestodene SCHEMBL5031715 1.00 PGR (1.00) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL14983004 1.00 PGR (1.00) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL15263394 1.00 PGR (1.00) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL16661464 1.00 PGR (1.00) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL1650027 1.00 PGR (1.00) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL2335657 1.00 PGR (1.00) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL354831 0.96 PGR (0.93) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL4467096 0.95 PGR (0.91) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL1467970 0.92 PGR (0.84) PGRARLMNASLC6A4ESR1
Gestodene SCHEMBL4473794 0.91 PGR (0.83) PGRARLMNASLC6A4ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6901 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4440706-B1 COMPOSITIONS FOR PROMOTING HAIR GROWTH ESTETRA SRL (BE) 2026-04-29 EP claimed
US-20260090995-A1 ORODISPERSIBLE DOSAGE UNIT CONTAINING AN ESTETROL COMPONENT ESTETRA SRL (BE) 2026-04-02 US claimed
US-20260053736-A1 LONG ACTING DRUG DELIVERY DEVICE AND ITS USE IN CONTRACEPTION BAYER OY (FI) 2026-02-26 US claimed
EP-4463570-B1 METHOD FOR HORMONE OR DRUG SCREENING IN A TISSUE SAMPLE ECOLE POLYTECHNIQUE FED LAUSANNE EPFL (CH) 2026-01-14 EP claimed
US-20260000613-A1 INJECTABLE CONTROLLED-RELEASE FORMULATIONS OF PROGESTOGEN DRUGS FORDOZ PHARMA CORP. (US) 2026-01-01 US claimed
EP-4653499-A2 SILICONE MATERIAL, SILICONE TUBE, IMPLANT, PHARMACEUTICAL COMPOSITION, AND TEST METHOD FOR AMOUNT OF DRUG RELEASED SHENYANG XINGHUA PHARMACEUTICAL TECHNOLOGY CO., LTD (CN) 2025-11-26 EP claimed
EP-4643858-A1 METHODS AND PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF UTERINE DISEASE Institut National de la Santé et de la Recherche Médicale (FR) 2025-11-05 EP claimed
EP-4637777-A1 USE OF ESTETROL IN HEPATICALLY IMPAIRED PATIENTS Estetra SRL (BE) 2025-10-29 EP claimed
US-12427114-B2 Orodispersible dosage unit containing an estetrol component ESTETRA SRL (BE) 2025-09-30 US claimed
EP-3787631-B1 MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR NASH AND OTHER METABOLIC DISORDERS UNIV EMORY (US) 2025-09-10 EP claimed
EP-0309263-A2 Hormone composition and use JENCAP RESEARCH LIMITED (CA) 1989-03-29 EP claimed
CN-1031323-A CONTRACEPTIVE IMPLANT AKZO NV (NL) 1989-03-01 CN claimed
EP-0303306-A1 Contraceptive implant AKZO N.V. (NL) 1989-02-15 EP claimed
US-4794119-A Aqueous crystalline suspension of steroid glycoesters SCHERING AKTIENGESELLSCHAFT (DE) 1988-12-27 US claimed
EP-0148724-B1 SEQUENTIAL COMBINED MULTIPHASE PREPARATION AND ITS USE FOR ORAL CONTRACEPTION SCHERING AKTIENGESELLSCHAFT (DE) 1988-06-01 EP claimed
WO-1988000469-A1 COMBINATION DOSAGE FORM FOR PRE-MENOPAUSAL WOMEN AMERICAN HOME PRODUCTS CORPORATION (US) 1988-01-28 WO claimed
EP-0253607-A1 Combination dosage form for premenopausal women AMERICAN HOME PRODUCTS CORPORATION (US) 1988-01-20 EP claimed
EP-0050867-B1 VAGINAL RING SCHERING AKTIENGESELLSCHAFT (DE) 1988-01-13 EP claimed
US-4621079-A GESTODENE AND ETHINYLESTRADIOL SCHERING AKTIENGESELLSCHAFT (DE) 1986-11-04 US claimed
US-4081537-A PROGESTATIONAL, OVULATION INHIBITORS, NIDATION INHIBITORS SCHERING AKTIENGESELLSCHAFT (DT) 1978-03-28 US claimed