Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 11/20 | 0.52 |
| ▸ | CDK1 | P06493 | 10/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 8/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.52 |
| ▸ | CDK9 | P50750 | 8/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.52 |
| ▸ | CDK7 | P50613 | 5/20 | 0.52 |
| ▸ | CCNH | P51946 | 5/20 | 0.52 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.52 |
| ▸ | JAK3 | P52333 | 9/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.47 |
| ▸ | SYK | P43405 | 3/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL14053387 | 0.88 | CDK2 (0.53) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL2471890 | 0.87 | JAK3 (0.63) | CDK2CDK1CCNT1CCNB1CDK9 | |
| Ammonia Solution, Strong SCHEMBL14053403 | 0.85 | CDK1 (0.50) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL17685307 | 0.84 | JAK3 (0.59) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL2475718 | 0.81 | NTRK1 (0.60) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL17685311 | 0.80 | CSF1R (0.56) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL17685281 | 0.78 | JAK3 (0.56) | CDK2CDK1CCNA2JAK3CDK5 | |
| SCHEMBL2470647 | 0.77 | CDK2 (0.53) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL4971164 | 0.76 | JAK3 (0.65) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL2473715 | 0.75 | JAK3 (0.64) | CDK2CDK1CCNT1CCNB1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420659-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| US-20120301486-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | Riger Pharmaceuticals, Inc. | 2012-11-29 | — | — | US | disclosed |
| US-8268851-B2 | Compositions and methods for inhibition of the JAK pathway | RIGEL PHARMACEUTICALS, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20100158921-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | RIGEL PHARMACEUTICALS, INC. (US) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100158921-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | CDK2 236/4885CDK1 155/4885CCNT1 1524/4885 |
| US-20120301486-A1 | COMPOSITIONS AND METHODS FOR INHIBITION OF THE JAK PATHWAY | JAK3, JAK2, JAK1 | CDK2 236/4885CDK1 155/4885CCNT1 1524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.