Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.60 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.60 |
| ▸ | MTOR | P42345 | 3/20 | 0.60 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.60 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21914801 | 0.85 | PIK3CA (0.71) | PIK3CAPIK3CDMTORPIK3R1AOC3 | |
| SCHEMBL2369411 | 0.85 | PIK3CA (0.60) | PIK3CAPIK3CDMTORAOC3HSD17B10 | |
| SCHEMBL2369996 | 0.79 | PIK3CA (0.71) | PIK3CAPIK3CDMTORAOC3 | |
| SCHEMBL244876 | 0.78 | HRH3 (0.65) | PIK3CAPIK3CDPIK3R1HSD17B10ALDH1A1 | |
| SCHEMBL13153211 | 0.77 | MTOR (0.61) | PIK3CAPIK3CDMTORPIK3R1HSD17B10 | |
| SCHEMBL628460 | 0.76 | MTOR (0.51) | PIK3CAMTORPIK3R1AOC3HSD17B10 | |
| SCHEMBL3730124 | 0.76 | PIK3CA (0.77) | PIK3CAPIK3CDMTORMAPTSMN1; SMN2 | |
| SCHEMBL1309097 | 0.75 | PIK3CA (1.00) | PIK3CAPIK3CDMTORPIK3R1PIK3CB | |
| SCHEMBL13298979 | 0.75 | PIK3CA (0.73) | PIK3CAPIK3CDMTORHSD17B10ALDH1A1 | |
| SCHEMBL5172881 | 0.75 | PIK3CA (1.00) | PIK3CAPIK3CDMTORHTTPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010120994-A2 | UREIDOARYL-AND CARBAMOYLARYL-MORPHOLINO- PYRIMIDINE COMPOUNDS, THEIR USE AS MTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESIS | WYETH LLC (US) | 2010-10-21 | — | — | WO | disclosed |