SCHEMBL372762

SCHEMBL372762

O=C(NC1C2CCN(CC2)C1Cc1cccnc1)c1ccc(-c2ccccn2)s1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 15/20 1.00
CHRNB2 P17787 15/20 1.00
CHRNA4 P43681 15/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL372763 1.00 CHRNA7 (1.00) CHRNA7CHRNB2CHRNA4
SCHEMBL372948 0.84 CHRNB2 (0.82) CHRNA7CHRNB2CHRNA4
SCHEMBL372640 0.84 CHRNB2 (1.00) CHRNA7CHRNB2CHRNA4
SCHEMBL11897000 0.84 CHRNB2 (1.00) CHRNA7CHRNB2CHRNA4
SCHEMBL29749473 0.84 CHRNB2 (1.00) CHRNA7CHRNB2CHRNA4
SCHEMBL372958 0.84 CHRNA7 (1.00) CHRNA7CHRNB2CHRNA4
SCHEMBL372639 0.84 CHRNB2 (1.00) CHRNA7CHRNB2CHRNA4
SCHEMBL11896985 0.84 CHRNB2 (1.00) CHRNA7CHRNB2CHRNA4
SCHEMBL372791 0.84 CHRNB2 (1.00) CHRNA7CHRNB2CHRNA4
Hydrochloric Acid SCHEMBL6523106 0.84 CHRNB2 (0.98) CHRNA7CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 59 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220211679-A1 ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2022-07-07 US claimed
EP-2945637-A1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS Novartis AG (CH) 2015-11-25 EP claimed
EP-2945633-A1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS Novartis AG (CH) 2015-11-25 EP claimed
EP-2945626-A1 USE OF ALPHA 7 NICOTINIC RECEPTOR AGONISTS FOR THE TREATMENT OF NARCOLEPSY Novartis AG (CH) 2015-11-25 EP claimed
US-20150313884-A1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS PHARMA AG (CH) 2015-11-05 US claimed
WO-2014111838-A1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2014-07-24 WO claimed
WO-2014111751-A1 USE OF ALPHA 7 NICOTINIC RECEPTOR AGONISTS FOR THE TREATMENT OF NARCOLEPSY NOVARTIS AG (CH) 2014-07-24 WO claimed
WO-2014111837-A1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2014-07-24 WO claimed
EP-2633868-A1 COMBINATION OF ALPHA 7 NICOTINIC AGONISTS AND ANTIPSYCHOTICS Targacept, Inc. (US) 2013-09-04 EP claimed
US-20110059947-A1 ALPHA 7 NICOTINIC AGONISTS AND ANTIPSYCHOTICS TARGACEPT, INC. (US) 2011-03-10 US claimed
EP-2254598-A2 ALPHA 7 NICOTINIC AGONISTS AND ANTIPSYCHOTICS Targacept Inc. (US) 2010-12-01 EP claimed
WO-2009102962-A2 COMBINATION OF ALPHA 7 NICOTINIC AGONISTS AND ANTIPSYCHOTICS TARGACEPT, INC. (US) 2009-08-20 WO claimed
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2025-02-04 US disclosed
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT NOVARTIS AG (CH) 2022-10-06 US disclosed
US-20220211679-A1 ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS NOVARTIS AG (CH) 2022-07-07 US disclosed
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment NOVARTIS AG (CH) 2022-06-14 US disclosed
WO-2010056622-A1 TREATMENT WITH ALPHA α7-SELECTIVE LIGANDS TARGACEPT, INC. (US) 2010-05-20 WO disclosed
EP-2185152-A2 ALPHA7 NACHR AGONISTS FOR TREATING OR PREVENTING METABOLIC DISORDERS Targacept Inc. (US) 2010-05-19 EP disclosed
WO-2009102962-A2 COMBINATION OF ALPHA 7 NICOTINIC AGONISTS AND ANTIPSYCHOTICS TARGACEPT, INC. (US) 2009-08-20 WO disclosed
WO-2009018511-A2 ALPHA7 NACHR AGONISTS FOR TREATING OR PREVENTING METABOLIC DISORDERS TARGACEPT, INC. (US) 2009-02-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110059947-A1 ALPHA 7 NICOTINIC AGONISTS AND ANTIPSYCHOTICS CHRNA7, CHRNA5, CHRNA4 CHRNA7 1/4885CHRNB2 14/4885CHRNA4 3/4885
US-12215387-B2 Biomarker predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885CHRNB2 9/4885CHRNA4 2/4885
US-20220211679-A1 ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS CHRNA7, CHRNA1, CHRNA4 CHRNA7 1/4885CHRNB2 16/4885CHRNA4 3/4885
US-20220316011-A1 BIOMARKER PREDICTIVE OF RESPONSIVENESS TO ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR ACTIVATOR TREATMENT CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885CHRNB2 9/4885CHRNA4 2/4885
US-11359241-B2 Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment CHRNA7, CHRNA4, CHRNA5 CHRNA7 1/4885CHRNB2 9/4885CHRNA4 2/4885
US-20150313884-A1 USE OF ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS CHRNA7, CHRNA1, CHRNA5 CHRNA7 1/4885CHRNB2 16/4885CHRNA4 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.