Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | DGKA | P23743 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 3/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.41 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL28238316 | 0.93 | MAPT (0.58) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL3734196 | 0.91 | MAPT (0.53) | MAPTDGKAKDM4EDUSP3MEN1 | |
| SCHEMBL1934156 | 0.89 | DGKA (0.59) | MAPTDGKAKDM4EDUSP3MEN1 | |
| 1,4-Butanediol SCHEMBL3728508 | 0.87 | DGKA (0.57) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Ethylene Glycol SCHEMBL3744656 | 0.87 | DGKA (0.57) | MAPTDGKAKDM4EDUSP3MEN1 | |
| SCHEMBL28920302 | 0.87 | DGKA (0.57) | MAPTDGKAKDM4EDUSP3MEN1 | |
| SCHEMBL3736669 | 0.86 | MAPT (0.49) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL3737026 | 0.85 | CYP1A2 (0.52) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL10781715 | 0.84 | MAPT (0.61) | MAPTDGKAKDM4EDUSP3MEN1 | |
| Propylene Glycol SCHEMBL28118309 | 0.83 | MAPT (0.65) | MAPTDGKAKDM4EDUSP3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7825178-B2 | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2010-11-02 | — | — | US | disclosed |
| US-20070289481-A1 | Leveling Agent for Floor Polish and Aqueous Floor Polish Composition | DAIHACHI CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-12-20 | — | — | US | disclosed |
| CN-101044221-A | Leveling agent for floor polish and aqueous floor polish composition | DAIHACHI CHEM IND (JP) | 2007-09-26 | — | — | CN | disclosed |