Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 4/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3717831 | 0.85 | ACACB (0.65) | ACACBSMN1; SMN2MTNR1AMTNR1BKDM4E | |
| SCHEMBL3717478 | 0.84 | ACACB (0.64) | ACACBSMN1; SMN2MTNR1AMTNR1BKDM4E | |
| SCHEMBL3720004 | 0.84 | ACACB (0.64) | ACACBSMN1; SMN2MTNR1AMTNR1BKDM4E | |
| SCHEMBL12001280 | 0.79 | ACACB (0.78) | ACACBSMN1; SMN2MTNR1AKDM4EALDH1A1 | |
| SCHEMBL3727055 | 0.78 | ACACB (0.56) | ACACBSMN1; SMN2MTNR1AMTNR1BKDM4E | |
| SCHEMBL3728643 | 0.78 | ACACB (0.61) | ACACB | |
| SCHEMBL3719665 | 0.76 | ACACB (0.54) | ACACBSMN1; SMN2MTNR1AMTNR1BKDM4E | |
| SCHEMBL255791 | 0.75 | ACACB (1.00) | ACACBSMN1; SMN2 | |
| SCHEMBL3719877 | 0.74 | SMN1; SMN2 (0.74) | SMN1; SMN2MTNR1AMTNR1BKDM4ELMNA | |
| SCHEMBL3727563 | 0.74 | ACACB (0.50) | ACACBSMN1; SMN2MTNR1AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | claimed |
| WO-2010127208-A1 | INHIBITORS OF ACETYL-COA CARBOXYLASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2010-11-04 | — | — | WO | disclosed |